Test your PPI hypothesis in a single day with the most carefully crafted collection of orthogonal techniques. We spent millions of dollars on biophysical equipment so you don't have to!
1. Binding and Kinetics
- SPR (Biacore 8000)
- Octet (Red384)
- BLI
- Fluorescence Polarization (FP)
- nanoDSF
- TR-Fret, FRET
- MS
2. Thermodynamics and Stoichiometry
- ITC
- MST (2Bind)
- SPR
3. Measure Conformational Changes
- Nuclear Magnetic Resonance (NMR)
- AVANCE III HD 800 MHz,
- AVANCE III 600 MHz
- AVANCE 300 MHz
- switchSENSE®
- Cryo-EM
- JEOL JSM-2000EX TEM
- JEOL JSM-IT100LA SEM
4. Protein analytics and Proteomics
- DSF
- DLS
- Mass spectrometry
- Thermo Scientific™ ISQ™ 7000 GC-MS system
- Thermo Scientific™ TSQ™ 9000 GC-MS/MS system
- Thermo Scientific™ Exactive™ GC Orbitrap™ GC-MS system
- Thermo Scientific™ Vanquish™ Flex Single Quad LC-MS system (with DAD and fraction collector)
- Thermo Scientific™ TSQ Altis Triple Quadrupole Mass Spectrometer (MS/MS)
- Thermo Scientific™ Q Exactive™ HF Hybrid Quadrupole-Orbitrap™ LC-MS system
- Thermo Scientific™ iCAP™ TQ Triple-Quad ICP-MS/MS with GC, IC, and LC capabilities
- Thermo Scientific™ Dionex™ ICS-6000 HPIC™ System
- Thermo Scientific Orbitrap Fusion Lumos
- Thermo Scientific™ TSQ Quantis™
5. New Technologies Being Evaluated
- Refeyn Mass photometry
- switchSENSE® dynamicBiosensors
- FidaBIO characterization of proteins & nanoparticles under native conditions
- AQS3pro brings protein secondary structure measurement