Literally everything you need for your early-stage drug discovery project, from START™ to finish, with 5 fully validated hits, guaranteed! We will customize the START™ workflow to meet the demands of your challenging new target. Studying the STING, NDM1, MCL1, or WDR5 pipelines? Yeah, we've got those too.
START™ packages include all of the following:
1. Target expertise in construct design
2. Highly Purified and Assay Ready Protein - (20- 100+mgs) tailored to each orthogonal technique
3. Select hits from fragment or unique chemical libraries
- Edelris (500-2200) novel 3D fragment library
- Enamine –2600 (pharma designed) frag libraries
- BioBlocks - Fragment or chemical libraries
- Icaria Standard Diversity set = 170,000
- CrystalFIRST (in silico and AI designed)
- 2BIND libraries
4. Validated HITS by one or more orthogonal screens
- switchSENSE
- NMR
- SPR
- ITC
- MST
- TSS
- SHG
- Mass spec
5. Structure determination platforms
- X-ray crystallography or CryoEM/TeM
- Soaking /co-crystallization system for target protein
- Data collection
- Structure determination
- Visualization